Analysis of Acquisition of COVID-2019 Neutralizing Antibodies in Organ Transplant Recipients.

BACKGROUND: This study confirmed the kinetics of antibodies acquired by SARS-CoV-2 vaccination in solid-organ transplant recipients and examined their association with the development of COVID-19 and immunosuppressive status in organ transplant recipients. METHODS: We measured COVID-19 neutralizing antibody titer in 21 organ transplant recipients vaccinated with the COVID-19 vaccine and 14 nontransplant recipients (control group) 3 times before and at 1 and 6 months after the third dose of vaccine. By confirming the kinetics of the acquired antibodies, we examined the relevance of the background characteristics of organ transplant recipients, such as the development of infectious diseases and immunosuppressive status. RESULTS: The proportion of patients with neutralizing antibodies was significantly higher in the nontransplant group than in the transplant group. Neutralizing antibody titers were significantly lower in transplant recipients when they were compared before the third dose and 1 month later. In the transplant recipient group, 11 patients were positive, and 10 were negative for neutralizing antibodies. When the causal relationship between the neutralizing antibody titer and background was examined, a positive correlation was found between the antibody titer and the number of years since transplantation, and a negative correlation was found between the tacrolimus trough values, amount of mycophenolate mofetil or steroids taken internally, and antibody titer. CONCLUSION: This study suggests that the effectiveness of vaccination in transplant recipients is associated with the post-transplant period before vaccination and the dose of immunosuppressive agents.

Analysis of Acquisition of Coronavirus Disease 2019 Neutralizing Antibodies in Organ Transplant Recipients

Background : This study confirmed the kinetics of antibodies acquired by SARS-CoV-2 vaccination in solid-organ transplant recipients and examined their association with the development of coronavirus disease 2019 (COVID-19) and immunosuppressive status in organ transplant recipients. Methods : We measured COVID-19 neutralizing antibody titer in 21 organ transplant recipients, who had been vaccinated with the COVID-19 vaccine, and 14 non-transplant recipients (control group) three times before and at 1 and 6 months after the third dose of vaccine. By confirming the kinetics of the acquired antibodies, we examined the relevance of the background characteristics of organ transplant recipients, such as the development of infectious diseases and immunosuppressive status. Result : The proportion of patients with neutralizing antibodies was significantly higher in the non-transplant group than in the transplant group. Neutralizing antibody titers were significantly lower in transplant recipients when they were compared before the third dose and at 1 month later. In the transplant recipient group, 11 patients were positive and 10 were negative for neutralizing antibodies. When the causal relationship between the neutralizing antibody titer and background was examined, a positive correlation was found between the antibody titer and the number of years since transplantation, and a negative correlation was found between the TAC trough values, amount of MMF or steroids taken internally, and antibody titer. Conclusion : This study suggests that the effectiveness of vaccination in transplant recipients is associated with the post-transplant period before vaccination and the dose of immunosuppressive agents.

Effects of media on preventive behaviour during the COVID-19 pandemic.

The novel coronavirus 2019 (COVID-19) pandemic required implementation of a variety of measures. In addition to pharmaceutical measures, such as vaccines, changing individuals' nonpharmaceutical preventive behaviour is essential to prevent the spread of infection. In uncertain situations, such as a pandemic, media sources are important for guiding individuals' decision-making behaviour. In this study, we examined the effects of media use on preventive behaviour during COVID-19. Earlier studies have shown that social networking service (SNS) browsing promotes preventive behaviour. However, those studies only assessed a single point during the early stages of the pandemic; therefore, the effects on ongoing preventive behaviour are unclear. Thus, a two-wave panel survey was conducted in 2020 and 2021 for an exploratory analysis of changes in the effects of media on individuals' preventive behaviour over time. The results show that the effect of SNS browsing on preventing going out was confirmed only during the early stage of the pandemic and was not observed 1 year later. It is also shown that those who shifted from self-restraint to going out within 1 year were not affected by the type of media use, but by cognitive factors. As the situation changes during a pandemic, analyses that consider time-series changes are essential for gaining insights about the effects of media on the promotion and maintenance of continuous prevention behaviours.